Dendritic cell vaccines for cancer therapy: fundamentals and clinical trials

GG Romagnoli, R Kaneno - … Bench to Bedside Immunotherapy of Cancers, 2021 - Springer
… to the effectiveness of lysate-pulsed DC vaccines. For instance, … In a phase I study, advanced
melanoma patients were … with total RNA of colorectal cancer cells previously submitted to …

… dendritic cells pulsed with lysate from an allogeneic hepatic cancer cell line as a treatment for patients with advanced hepatocellular carcinoma: a pilot study

MTA Ghafar, MA Morad, EA El-Zamarany… - International …, 2020 - Elsevier
lysate-pulsed DCs vaccine as intradermal injections in the … of 5 patients with stage D 3
patients advanced to stage B and … Dendritic cell vaccination for metastatic melanoma: a 14-year …

CTLA-4 silencing in dendritic cells loaded with colorectal cancer cell lysate improves autologous T cell responses in vitro

F Ghorbaninezhad, J Masoumi… - Frontiers In …, 2022 - frontiersin.org
… in CRC cell lysate-pulsed-DCs via transfection of siRNA to enhance the efficacy of DC-based …
Efficient nontoxic delivery of PD-L1 and PD-L2 siRNA into dendritic cell vaccines using the …

Preliminary report of a novel formulation of clinical-grade, fully matured, tumor-associated peptide-loaded dendritic cells for cancer immunotherapy

L Mirandola, M Chiriva-Internati, R Bresalier… - Translational Medicine …, 2019 - Springer
dendritic cells for autologous therapeutic cancer vaccines. We … Two of them had refractory
colorectal cancer (CRC), and one … CTLA4 blockade in patients with metastatic melanoma. Clin …

Comparison of four methods of colon cancer cell lysates preparation for ex vivo maturation of dendritic cells

M Roufarshbaf, N Esmaeil, V Akbari - Research in Pharmaceutical …, 2022 - journals.lww.com
… are approved for regionally metastatic colorectal cancer but have … studies, the DC-based
vaccine is one of the safe cancer … exhibited greater in vivo protection against melanoma than …

Personalized dendritic cell vaccines—recent breakthroughs and encouraging clinical results

B Mastelic-Gavillet, K Balint, C Boudousquie… - Frontiers in …, 2019 - frontiersin.org
… -derived and tumor lysate-pulsed mature DC-based vaccine (APCEDEN … phase 3 study is
currently evaluating active immunization in adjuvant therapy of patients with stage 3 melanoma

Immune dysfunctions and immunotherapy in colorectal cancer: the role of dendritic cells

S Gessani, F Belardelli - Cancers, 2019 - mdpi.com
patients in an advanced disease stage often included the use of cytokines (ie, IFN, IL-2),
adoptive cell therapy and DC-based vaccines, … in patients with metastatic melanoma [71] and …

Dendritic Cells in Cancer Immunology and Immunotherapy

L Hato, A Vizcay, I Eguren, JL Pérez-Gracia… - Cancers, 2024 - mdpi.com
… of dendritic cell vaccines in different solid tumors regarding … year, colorectal cancer (CRC)
is the second leading cause of … were feasible and safe in advanced melanoma patients [35]. …

Antitumour dendritic cell vaccination in a priming and boosting approach

A Harari, M Graciotti, M Bassani-Sternberg… - Nature Reviews Drug …, 2020 - nature.com
… the foundation of a phase I study for the treatment of metastatic melanoma in which a 3D …
an autologous tumour lysate is implanted in patients with melanoma (NCT01753089). For 3D …

Autologous dendritic cells loaded with antigens from self-renewing autologous tumor cells as patient-specific therapeutic cancer vaccines

RO Dillman, GI Nistor, HS Keirstead - Human Vaccines & …, 2023 - Taylor & Francis
… The most convincing serologic data for desirable immune responses in our cancer trials
came from the melanoma randomized trial in which there were obvious changes in clusters of …